Objective: This study aimed to evaluate the microbiological profile and antibiotic susceptibility patterns in patients undergoing drainage for pilonidal sinus abscess and to assess the efficacy of an empirical cefuroxime-ciprofloxacin regimen.Methods: Between November 2021 and February 2024, 88 patients who underwent drainage for pilonidal abscess at Balıklıgöl State Hospital and Harran University Faculty of Medicine Hospital were included.
Pus cultures were obtained under sterile conditions. Patients received cefuroxime 500 mg (twice daily) and ciprofloxacin 500 mg (twice daily) postoperatively. Treatment success was defined as resolution of erythema and pain by day 7. Culture results and antibiograms were analyzed descriptively.Results: İn the study included 63.6% of the patients were male (n=56), and 36.4% (n=32) were female.
Staphylococcus (41.2%) and Streptococcus (31.4%) were the predominant isolates. Resistance to the empirical regimen occurred in 3 cases (3.4%), requiring escalation. The overall success rate was 96.6%. Culture negativity (42%) was noted but did not impact outcomes.Conclusion: Pilonidal abscess microbiologically resembles skin/soft tissue infections.
The cefuroxime-ciprofloxacin combination demonstrated high efficacy, though regional resistance patterns and anaerobic coverage merit further study.